ELTS, Sokal, and Hasford Scores

Ova alatka služi isključivo u obrazovne svrhe i ne predstavlja profesionalni savet niti zamenu za profesionalni savet. Alatku ne treba koristiti za postavljanje medicinske dijagnoze i/ili pružanje medicinske terapije.

Opšti opis
Ova alatka izračunava prognostičku rizičnu grupu EUTOS skora za dugoročno preživljavanje (ELTS), Sokal i Euro skor (Hasford) za odrasle pacijente sa dijagnozom hronične mijeloidne leukemije (CML). Skor se izračunava na osnovu starosti pacijenta, veličine slezine, blasta u perifernoj krvi i broja trombocita. Na osnovu ocene rizika pacijent se svrstava u jednu od tri grupe: niskorizična, srednjerizična i visokorizična.

ELTS score =
0.0025 × (age in completed years/10)³
+ 0.0615 × spleen size below costal margin
+ 0.1052 × blasts in peripheral blood
+ 0.4104 × (platelet count/1000)⁻½

Sokal score =
exp ((0.0116 × (age [years] – 43.4))
+ (0.0345 × (spleen size [cm] – 7.51))
+ (0.188 × ((platelets [10⁹/L]/700)² – 0.563))
+ (0.0887 × (blasts [%] – 2.10)))

Hasford score =
((0.6666 × age [0 when age < 50 years; 1 otherwise])
+ (0.0420 × spleen size [cm])
+ (0.0584 × blasts [%])
+ (0.0413 × eosinophils [%])
+ (0.2039 × basophils [0 when basophils < 3%; 1 otherwise])
+ (1.0956 × platelet count [0 when platelets < 1500 × 10⁹/L; 1 otherwise])) × 1000

Sokal JE, Cox EB, Baccarani M, et al. Prognostic discrimination in “good-risk” chronic granulocytic leukemia. Blood 1984; 63: 789-99.

Hasford J, Pfirrmann M, Hehlmann R, et al. A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. J Natl Cancer Inst. 1998; 90: 850-8.

Pfirrmann M, Baccarani M, Saussele S, et al. Prognosis of long-term survival considering disease-specific death in patients with chronic myeloid leukemia. Leukemia 30;48–56 (2016).

Hochhaus A, Saussele S, Rosti G, et al. Chronic myeloid leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology. 2017;28(4):iv41–iv51.