PaO₂/FiO₂ Ratio
Horovitz Index for Lung function
Допълнителна информация
Предупреждение
Този инструмент е преднаначен само за образователни цели и не представлява професионален съвет или заместител на професионален съвет. Инструментът не трябва да се използва за предоставяне на медицинска диагноза и/или лечение.
General description
Acute respiratory distress syndrome (ARDS) is a form of inflammatory lung injury associated with high mortality. ARDS and its severity grading are defined mainly by the P/F ratio, also known as the Horovitz index, which is calculated by dividing the arterial partial pressure of oxygen (PaO₂) with the inspired oxygen concentration (FiO₂) and represents a measure of hypoxemia.
The 2012 Berlin definition of ARDS recognizes 3 grades of ARDS severity: mild (P/F ratio 201–300 mmHg), moderate (P/F ratio 101–200 mmHg), and severe (P/F ratio ≤ 100 mmHg), each associated with considerably increased mortality (27 %, 32 %, and 45 % respectively). As P/F ratio can be markedly affected by the positive end-expiratory pressure (PEEP), a minimum level of PEEP (≥ 5 cm H₂O) was also included in the definition of ARDS.
Acute respiratory distress syndrome (ARDS) is a form of inflammatory lung injury associated with high mortality. ARDS and its severity grading are defined mainly by the P/F ratio, also known as the Horovitz index, which is calculated by dividing the arterial partial pressure of oxygen (PaO₂) with the inspired oxygen concentration (FiO₂) and represents a measure of hypoxemia.
The 2012 Berlin definition of ARDS recognizes 3 grades of ARDS severity: mild (P/F ratio 201–300 mmHg), moderate (P/F ratio 101–200 mmHg), and severe (P/F ratio ≤ 100 mmHg), each associated with considerably increased mortality (27 %, 32 %, and 45 % respectively). As P/F ratio can be markedly affected by the positive end-expiratory pressure (PEEP), a minimum level of PEEP (≥ 5 cm H₂O) was also included in the definition of ARDS.
Formula
Horowitz Index is calculated as PaO₂ [mmHg] divided by FiO₂.
ARDS severity
Not ARDS
> 300 mmHgMild ARDS
201–300 mmHgModerate ARDS
101–200 mmHgSevere ARDS
< 101 mmHgReferences
ARDS Definition Task Force et al. “Acute respiratory distress syndrome: the Berlin Definition.” JAMA vol. 307,23 (2012): 2526-33. doi:10.1001/jama.2012.5669
Griffiths, Mark J D et al. “Guidelines on the management of acute respiratory distress syndrome.” BMJ open respiratory research vol. 6,1 e000420. 24 May. 2019, doi:10.1136/bmjresp-2019-000420
Tasaka, Sadatomo et al. “ARDS Clinical Practice Guideline 2021.” Journal of intensive care vol. 10,1 32. 8 Jul. 2022, doi:10.1186/s40560-022-00615-6
Horovitz, J H et al. “Pulmonary response to major injury.” Archives of surgery (Chicago, Ill. : 1960) vol. 108,3 (1974): 349-55. doi:10.1001/archsurg.1974.01350270079014
Версия
1
Относно този инструмент
Acute respiratory distress syndrome (ARDS) is a form of inflammatory lung injury associated with high mortality. ARDS and its severity grading are defined mainly by the P/F ratio, also known as the Horovitz index, which is calculated by dividing the arterial partial pressure of oxygen (PaO₂) with the inspired oxygen concentration (FiO₂) and represents a measure of hypoxemia.
The 2012 Berlin definition of ARDS recognizes 3 grades of ARDS severity: mild (P/F ratio 201–300 mmHg), moderate (P/F ratio 101–200 mmHg), and severe (P/F ratio ≤ 100 mmHg), each associated with considerably increased mortality (27 %, 32 %, and 45 % respectively). As P/F ratio can be markedly affected by the positive end-expiratory pressure (PEEP), a minimum level of PEEP (≥ 5 cm H₂O) was also included in the definition of ARDS.
The 2012 Berlin definition of ARDS recognizes 3 grades of ARDS severity: mild (P/F ratio 201–300 mmHg), moderate (P/F ratio 101–200 mmHg), and severe (P/F ratio ≤ 100 mmHg), each associated with considerably increased mortality (27 %, 32 %, and 45 % respectively). As P/F ratio can be markedly affected by the positive end-expiratory pressure (PEEP), a minimum level of PEEP (≥ 5 cm H₂O) was also included in the definition of ARDS.
