McDonald Diagnostic Criteria for Multiple Sclerosis
2017 Revision
Diagnosis of multiple sclerosis in patients with an attack* at onset
Diagnosis of multiple sclerosis in patients with a disease course characterised by progression from onset (primary progressive multiple sclerosis)
* See references for more info
Dodatne informacije
Upute i reference
Upozorenje
Ovaj je alat namijenjen samo za obrazovne svrhe i ne predstavlja stručni savjet niti zamjenu za stručni savjet. Alat se ne smije upotrebljavati za medicinsku dijagnostiku i/ili liječenje.
Općeniti opis
Ovaj alat izračunava ispunjavaju li pacijenti McDonaldove kriterije za multiplu sklerozu iz 2017. godine za pacijente s napadom na početku bolesti i za pacijente čiji tijek bolesti karakterizira njena progresija od početka (primarna progresivna multipla skleroza).
Ovaj alat izračunava ispunjavaju li pacijenti McDonaldove kriterije za multiplu sklerozu iz 2017. godine za pacijente s napadom na početku bolesti i za pacijente čiji tijek bolesti karakterizira njena progresija od početka (primarna progresivna multipla skleroza).
*Attack
A monophasic clinical episode with patient-reported symptoms and objective findings reflecting a focal or multifocal inflammatory demyelinating event in the CNS, developing acutely or subacutely, with a duration of at least 24 h, with or without recovery, and in the absence of fever or infection; similar to a typical multiple sclerosis relapse (attack and exacerbation) but in a patient not known to have multiple sclerosis. A clinically isolated syndrome can be monofocal (reflecting pathology in a single location) or multifocal; the specific manifestations of a clinically isolated syndrome depend on the anatomical location (or locations) of the pathology. Typical presentations include unilateral optic neuritis, focal supratentorial syndrome, focal brainstem or cerebellar syndrome, or partial myelopathy; examples of atypical presentations include bilateral optic neuritis, complete ophthalmoplegia, complete myelopathy, encephalopathy, headache, alteration of consciousness, meningismus, or isolated fatigue.
Criteria for diagnosis of multiple sclerosis in patients with an attack at onset
Patient is classified as having MS if:
• They have ≥ 2 attacks and ≥ 2 lesions
• They have ≥2 attacks and 1 lesion and historical evidence of a previous attack involving a lesion in a distinct anatomical location
• They have ≥ 2 attacks and 1 lesion and dissemination in space
• They have 1 attack and ≥ 2 lesions and dissemination in time
• They have 1 attack and 1 lesion and dissemination in time and dissemination in space
• They have ≥ 2 attacks and ≥ 2 lesions
• They have ≥2 attacks and 1 lesion and historical evidence of a previous attack involving a lesion in a distinct anatomical location
• They have ≥ 2 attacks and 1 lesion and dissemination in space
• They have 1 attack and ≥ 2 lesions and dissemination in time
• They have 1 attack and 1 lesion and dissemination in time and dissemination in space
Criteria for diagnosis of multiple sclerosis in patients with a disease course characterised by progression from onset (primary progressive multiple sclerosis)
Patients are classified as having MS if primary criteria is fulfilled and two of the secondary criteria are fulfilled.
Reference
Thompson AJ, Banwell BL, Barkhof F, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018; 17 (2): 162–73.
NICE guidelines. Multiple sclerosis in adults: management. Clinical guideline 186. Published: 8 October 2014.
Verzija
1
O ovom alatu
Ovaj alat izračunava ispunjavaju li pacijenti McDonaldove kriterije za multiplu sklerozu iz 2017. godine za pacijente s napadom na početku bolesti i za pacijente čiji tijek bolesti karakterizira njena progresija od početka (primarna progresivna multipla skleroza).
